Lung Function Impairment and the Risk of Incident Dementia: The Rotterdam Study

Background: The etiology of dementia may partly be underpinned by impaired lung function via systemic inflammation and hypoxia. Objective: To prospectively examine the association between chronic obstructive pulmonary disease (COPD) subclinical impairments in risk dementia. Methods: In Rotterdam Study, we assessed incident participants with Preserved Ratio Impaired Spirometry (PRISm; FEV1/FVC?0.7, FEV1 < 80% predicted) COPD (FEV1/FVC 0.7) compared to those normal spirometry (controls; FEV1?80% predicted). Hazard ratios (HRs) 95% confidence intervals (CI) for were adjusted age, sex, education attainment, smoking status, systolic blood pressure, body mass index, triglycerides, comorbidities Apolipoprotein E (APOE) genotype. Results: Of 4,765 participants, 110 (2.3%) developed after 3.3 years. Compared controls, PRISm, but not COPD, had an increased all-type (adjusted HRPRISm 2.70; CI, 1.53–4.75; HRCOPD 1.03; 0.61–1.74). These findings primarily driven men smokers. Similarly, FVC% predicted values lowest quartile highest at HR 2.28; 1.31–3.98), as well Alzheimer’s (AD; 2.13; 1.13–4.02). Conclusion: Participants PRISm or a low dementia, higher predicted, respectively. Further research is needed elucidate whether this causal how might contribute pathogenesis.